Are post-mortem biochemical studies of human brain worthwhile?

et al., 1981), a value similar to that for the proteinase solubilized from myelin membranes. When the metalloproteinase activity from myelin membranes is purified to homogeneity it can be compared more accurately with meprin and endopeptidase 24.1 5. In addition, antibodies against this proteinase should permit immunoelectron microscopy to pinpoint its subcellular localization in the nervous system. We thank the Multiple Sclerosis Society for financial support, Nigel Groome (Oxford Polytechnic) for preparing mono-specific antibodies to MBP epitopes, Jeff Keen and John Findlay (University of Leeds) for N-terminal sequencing, and Nicola Woodroofe and Gillian Hayes (MS Society Laboratory) for immunohistochemistry.